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INTRODUCTIONThe pharmacologically treatable disorders of impairements of normal motility, digestion, absorption, secretions of the gastrointestinal tract include peptic ulcer, reflux esophagitis, Zollinger-Ellison syndrome, gastroparesis, constipation, diarrhea, inflammatory diseases and infections. This chapter discusses different drugs used for treatment of these disorders. However, anti-infective drugs will be discussed in other chapter.
Drugs used in Acid-peptic disease:Acid-peptic disease includes peptic ulcer (gastric and duodenal), gastroesophageal reflux and Zollinger – Ellison syndrome.Peptic – ulcer disease is thought to result from an imbalance between cell – destructive effects of hydrochloric acid and pepsin and cell-protective effects of mucus and bicarbonate on the other side. Pepsin is a proteolyic enzyme activated in gastric acid, also can digest the stomach wall.
A bacterium, Helicobacter pylori is now accepted to be involved in the pathogenesis of ulcer.In gastroesophageal reflux, acidic stomach contents enter into the esophagus causing a burning sensation in the region of the heart; hence the common name heartburn, or other names such as indigestion, dyspepsia, pyrosis, etc.
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