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INTRODUCTIONIn the past decades, cardiovascular diseases were considered as major health problems mainly for western countries. However, the problem of cardiovascular disorders is also increasing in developing countries including Ethiopia. The most commonly encountered cardiovascular disorders include hypertension, congestive heart failure, angina pectoris and cardiac arrhythmias. Most drugs available currently are able to reduce the morbidity and mortality due to these disorders, and therefore, this chapter discusses the pharmacology of these drugs.
I. Antihypertensive drugsa. General consideration:-Hypertension is defined as an elevation of arterial blood pressure above an arbitrarily defined normal value. The American Heart Association defines hypertension as arterial blood pressure higher than 140/90mmHg (based on three measurements at different times).Hypertension may be classified in to three categories, according to the level of diastolic blood pressure:
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